Muchinjikwa-Yakabatanidzwa sodium hyaluronate gel yekuvhiya


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Ikozvino yakagadzirwa inoenderana ne-cross-linked sodium hyaluronate gel yetishu filler yekuvhiya epurasitiki uye nzira yekugadzirira iyo.Iyo alkaline solution ye sodium hyaluronate inobata neketani refu alkane ine epoxy group uye muchinjiko-inobatanidza agent ine epoxy group kwemaawa 2˜5 pa 35° C.˜50° C. kuti ibudise cross-linked sodium hyaluronate, yobva yasukwa, gelled uye sterilized, kugadzirira gel.Pakati payo, iyo molar ratio ye sodium hyaluronate: cross-linking agent ine epoxy group: long chain alkane ine epoxy group ndeye 10: 4˜1: 1˜4;nhamba yemaatomu ekabhoni eiyo yakataurwa refu cheni alkane ine epoxy boka ndeye 6 kusvika 18. Iyo gel yakagadzirwa mune yazvino yakagadzirwa inogona, kune rumwe rutivi, inobudirira kusimudzira kushorwa kweenzymolysis kuti iwedzere kugadzikana, uye kune rumwe rutivi, kuchengetedza. iyo yakanakisa biocompatibility yesodium hyaluronate pasina kukanganisa kubaya kwayo.

Crosslinked sodium hyaluronate gel yekuvhiya epurasitiki yekuvhiya uye nzira yekugadzirira iyo:

Iyo yakagadzirwa ine chekuita nenzira yekugadzirira ye-cross-yakabatanidzwa sodium hyaluronate gel yekuvhiya epurasitiki yekuvhiya, iyo inoratidzwa nekusanganisira anotevera matanho:
(1) Sodium hyaluronate poda yakaoma yakaparadzirwa mu10?wt%~20?Mushonga wakavhenganiswa wakaumbwa ne wt% sodium hydroxide aqueous solution uye acetone yakashandiswa kuwana sodium hyaluronate basic suspension, uyezve crosslinking agent 1,4?Butanediol diglycidyl ether BDDE inosanganiswa zvakaenzana kuti iwane maitiro ekugadzirisa, kuitira kuti utange maitiro ekubudisa cross-linked sodium hyaluronate;Pasi pemamiriro ezvinhu anomutsa, maitiro anopedzwa mushure mokunge maitiro ekugadzirisa akachengetwa pa 35 ℃ ~ 50 ℃ kwemaawa 5 ~ 8, uye pH kukosha kweiyo yakasimba-yemvura yakasanganiswa zvinhu mushure mekuita kunogadziriswa ku7 ne concentrated hydrochloric acid;Ndekupi uko kusungirirwa kwesodium hyaluronate mune yekuita zvinhu ndeye 2?Wt% ~ 5wt%, kuwanda kwehuwandu hwe crosslinking agent kune sodium hyaluronate ndeye (1: 1.3) ~ (1: 1.8);
(2) Sefa musanganiswa wakasimba uye wemvura wepH = 7 mushure mekuita kuti ubvise mvura.Izvo zvakasara zvinogezwa neacetone kuGC?MS kuona zvirimo muBDDE pazasi 2ppm.Zvinhu zvakasara zvinosanganisira chena hupfu uye läkujeka gel, uye ipapo dzakaomeswa zvinhu vacuum akaomeswa kuwana mvura-isingasviki chena yakaoma upfu, kureva, muchinjiko kwakabatana sodium hyaluronate upfu.
(3) Sieving uye kupatsanura crosslinked sodium hyaluronate poda inowanikwa vacuum kuomesa munhanho ② uye kuunganidza sieved poda;
(4) Kuwedzera mvura yakasvibiswa paupfu yakasefa yakaunganidzwa munhanho 3, kuitira kuti iyo yakasanganiswa sodium hyaluronate poda yakazvimba uye inonatswa kwemaawa 6 ~ 10 pakupisa kwekamuri kubva pa15 kusvika ku35 madhigirii, uye zvikamu zvegel zvinounganidzwa kusvika tora crosslinked sodium hyaluronate gel.
(5) Iyo isotonic PBS buffer yakawedzerwa kune gel yakaunganidzwa padanho rechina uye yakacheneswa kwe6 ~ 10 maawa pakamuri tembiricha kubva 15 kusvika 35 madhigirii.Mushure mekusefa, PBS yakabviswa uye gel yakaunganidzwa.Iyo gel yakaongororwa sequentially nekushandisa yekutanga kududzirwa uye yechipiri zvirevo zvekrini.3 saizi dzakasiyana dzemagero dzakawanikwa, uye 3 gels dzakaitwa sterilized uye dzakazadzwa mune pre sterilized disposable sirinji.


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